36. Using Different Runways for Takeoffs and Landings
If you have an airport with more than one runway then it is easy to have ATC assign aircraft to takeoff from one runway and land on another. This applies to both the AI and your own aircraft.

In Flight Simulator, ATC will assign the longest runway that faces the wind as the active runway for both takeoffs and landings. You can flag that runway as closed for takeoffs. ATC will continue to assign that runway for landings but will then assign the next longest runway for takeoffs. Conversely, you can flag the runway as closed for landings and ATC will continue to assign that runway for takeoffs but will assign the next longest runway for landings. Here are the instructions: