I can't give you a definite on that since I only know of it successfully tested with FS9 and MSOS XP, both of which predate it (the operating system needs to acknowledge the operational characteristics).

However, since I use a USB MS Precision Pro 2 joystick, which has control buttons not on a basic joystick, a multifunction unit obviously can work with CFS; there are device CFGs as well as a specific entry section in the COMBAT.CFG for the joystick (where the key control designations are located).