Clinton, the only advice I'd give you is twofold:

A) If you have some experience with another VA first, it'll make things much easier for you when you decide to launch your own.

B) If you absolutely INSIST on running your own straight out of the gate (which is what I did, and I semi-regret it), then stick with it.  VA's are only a tiny portion of an already only moderate hobby (simming), so you need to stick with it.  Airlines come and go like pages in a calendar, so people need to see that you're going to stick around before they'll sign up.  It's not easy, but it's not impossible either.  No one gets 50 pilots in their first day, so don't even try.  Just make it the best airline you can, and if people come, cool.  If not, find out why not and fix it!

If you've got any other questions, gimme a shout!